A functional role for structural variation in metabolism
نویسندگان
چکیده
منابع مشابه
A functional role for structural variation in metabolism
A contribution of structural genomic variation to the heritability of complex metabolic phenotypes was illuminated by the recent characterization of chromosome-engineered mouse models for genomic disorders associated with metabolic dysfunction. Herein we discuss our study, "A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice a...
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A Role for Gene Duplication and Natural Variation of Gene Expression in the Evolution of Metabolism
BACKGROUND Most eukaryotic genomes have undergone whole genome duplications during their evolutionary history. Recent studies have shown that the function of these duplicated genes can diverge from the ancestral gene via neo- or sub-functionalization within single genotypes. An additional possibility is that gene duplicates may also undergo partitioning of function among different genotypes of ...
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ژورنال
عنوان ژورنال: Adipocyte
سال: 2013
ISSN: 2162-3945,2162-397X
DOI: 10.4161/adip.22031